News

In a development that sheds new light on the pathology of Alzheimer’s disease (AD), a team of Whitehead Institute scientists has identified connections between genetic risk factors for the disease and the effects of a peptide toxic to nerve cells in the brains of AD patients.

Using an unusual human cell line of this type, Whitehead Institute researchers and their collaborators performed a genetic screen and identified a protein used by Ebola virus to gain entry into cells and begin replicating. The discovery may offer a new approach for the development of antiviral therapeutics.

New findings by scientists at the Broad Institute of MIT and Harvard and Whitehead Institute point to a decentralized society in tumors, with cancer cells able to interconvert between different types. These results have potential implications for the treatment of tumors, in particular, that attacking cancer stem cells alone may not be enough to fight cancer.

Whitehead Institute researchers have discovered how yeast cells protect themselves against a novel type of chromosome fragility that occurs in repeated DNA during meiosis—the cell division that produces spores in fungi or eggs and sperm in plants and animals.

Using a new in vivo screening system, Whitehead Institute researchers have identified a protein in a key metabolic pathway that is essential in estrogen receptor (ER)-negative breast cancer.

Using two distinct methods, Whitehead Institute researchers have successfully and consistently manipulated targeted genes in both human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells (adult cells that have been reprogrammed to an embryonic stem cell-like state).

The Pew Charitable Trusts has named Whitehead Institute Member Mary Gehring a 2011 Pew Scholar in the Biomedical Sciences.

Researchers in the lab of Whitehead Institute Member David Sabatini have identified a previously unknown substrate of the mammalian target of rapamycin (mTOR) kinase, called Grb10. Linking Grb10 activity to mTOR provides a more detailed understanding of the function of mTOR and may open up new areas for mTOR research.

Whitehead Institute researchers have identified signals impinging on breast epithelial cells that can induce those cells to acquire and stably display migratory and self-renewing characteristics.

Whitehead Institute researchers have found that depriving human melanoma cells of the amino acid leucine can be lethal to the cells, suggesting a possible strategy for therapeutic intervention. The researchers observed the effect in melanoma cells with a mutation in the RAS/MEK signaling pathway—the most common mutation found in the deadliest form of skin cancer.