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TabulaSynthase, the blog of Whitehead Institute, brings together ideas and perspectives from the Whitehead community and beyond. These days, few people spend fifty years working in one organization. Fewer still have loved just about every minute of that time. And only a handful of those have had a huge impact on their field. Harvey Lodish — a powerhouse in the fields of cellular and developmental biology, and a beloved teacher and mentor — considers himself lucky to be among that handful. 

Postdoctoral researchers Anna Boija and Isaac Klein from Whitehead Institute Member Richard Young's lab identified a new way that transcription factors and co-activators can interact and activate transcription. The activation domain of transcription factors sets up the formation of a liquid droplet on the genome containing key factors involved in regulating transcription.

Danielle Tomasello is a postdoctoral fellow investigating neurodevelopmental disorders in Whitehead Institute Member Hazel Sive’s lab. Tomasello is a Simons Center for the Social Brain fellow and was previously Whitehead Institute’s Balkin-Markell-Weinberg Fellow. She is also the creator of The Social Scientist, an outreach and networking site for scientists. We sat down with Tomasello to learn a bit more about her and her experiences in the lab.

Some of the newest and brightest at Whitehead Institute discuss their current research and the future of science. Speakers include - Whitehead Institute Fellow Olivia Corradin: Uncovering New Insights into Human Disease from Genetic Risk Factors - Whitehead Institute Member Ankur Jain: Liquids, Gels, and Neurodegeneration - Whitehead Institute Fellow Kristin Knouse: Innovation in Regenerative Medicine Moderated by Nancy C. Andrews, MD, PhD, former dean of Duke University School of Medicine

Leah Bury  is a postdoc in the lab of Whitehead Member Iain Cheeseman, where her research is focused on understanding transcription of DNA into RNA at the centromere, a region of the chromosome important in cell division.